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Home / Primary Antibodies / Promotion

KLRK1 antibody

SKU : BHA10810431

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Mfr.No.	FNab10477
Background	Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
Clonality	polyclonal
Host	Rabbit
Immunogen	NKG2-D type II integral membrane protein
Immunogen Region	NKG2-D type II integral membrane protein
Isotype	IgG
Molecular Weight	30 kDa
Reactivity	Human, Mouse
Recommended Dilution	WB: 1:500-1:2000
Synonyms	KLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D

Uniprot	P26718
Gene Id	22914

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:2000

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10477.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810431	FNab10477	100ug	$300		Add to Cart

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