Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.
Clonality
polyclonal
Host
Rabbit
Immunogen
interferon regulatory factor 2 binding protein 2
Immunogen Region
interferon regulatory factor 2 binding protein 2
Isotype
IgG
Molecular Weight
61 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Synonyms
IRF 2 binding protein 2, IRF 2BP2, IRF2BP2
Uniprot
Q7Z5L9
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10716.pdf" target="_blank">Data Sheet</ a>