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Home / Primary Antibodies / Polyclonal Antibodies

GPX2 antibody

SKU : BHA10810445

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Mfr.No.	FNab10491
Background	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alteatively spliced transcript variants have been found for this gene.
Clonality	polyclonal
Host	Rabbit
Immunogen	Glutathione peroxidase 2
Immunogen Region	Glutathione peroXidase 2
Isotype	IgG
Molecular Weight	21 kDa
Reactivity	Human, Mouse, Rat
Recommended Dilution	WB: 1:500-1:2000; IHC: 1:50-1:200
Synonyms	GPX2, GI-GPx, GPRP, GPRP-2

Uniprot	P18283

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:2000; IHC: 1:50-1:200

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10491.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810445	FNab10491	100ug	$300		Add to Cart

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