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Home / Primary Antibodies / Promotion

GNE antibody

SKU : BHA10803538

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Mfr.No.	FNab03544
Alternative Names	GLCNE
Background	The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alteative splicing of this gene results in transcript variants encoding different isoforms.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
Host	Rabbit
Immunogen	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Isotype	IgG
Molecular Weight	70-120 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	GLCNE

Uniprot	Q9Y223
Gene Id	10020
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab03544.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803538	FNab03544	100ug	$300		Add to Cart

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