This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alteative splicing results in multiple transcript variants encoding distinct isoforms.
Categories
Primary Antibodies
Clonality
polyclonal
Description
GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Host
Rabbit
Immunogen
glial fibrillary acidic protein
Isotype
IgG
Molecular Weight
50 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
FLJ45472, GFAP
Uniprot
P14136
Gene Id
2670
Research Area
Stem Cells, Immunology, Cancer, Neuroscience
Weight
50kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)