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Home / Primary Antibodies / Polyclonal Antibodies

FZR1 antibody

SKU : BHA10803259

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Mfr.No.	FNab03265
Alternative Names	CDH1 ; FYR ; FZR ; KIAA1242
Categories	Primary Antibodies
Clonality	polyclonal
Description	Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Host	Rabbit
Immunogen	fizzy/cell division cycle 20 related 1 (Drosophila)
Isotype	IgG
Molecular Weight	55 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	CDH1, FYR, FZR, KIAA1242

Uniprot	Q9UM11
Gene Id	51343
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:50

Manual	FNab03265.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803259	FNab03265	100ug	$300		Add to Cart

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