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Home / Primary Antibodies / Polyclonal Antibodies

FUBP1 antibody

SKU : BHA10803229

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Mfr.No.	FNab03235
Background	The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alteative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.
Host	Rabbit
Immunogen	far upstream element (FUSE) binding protein 1
Isotype	IgG
Molecular Weight	79 kDa
Reactivity	Human, Mouse
Regulatory	RUO

Uniprot	Q96AE4
Gene Id	8880
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IP
Description	ELISA ; WB ; IF ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab03235.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803229	FNab03235	100ug	$300		Add to Cart

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