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Home / Primary Antibodies / Promotion

FGF1 antibody

SKU : BHA10803081

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Mfr.No.	FNab03087
Alternative Names	FGFA
Background	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alteatively spliced variants encoding different isoforms have been described.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent teary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
Host	Rabbit
Immunogen	fibroblast growth factor 1 (acidic)
Isotype	IgG
Molecular Weight	17 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	FGFA

Uniprot	P05230
Gene Id	2246
Research Area	Developmental biology, Signal Transduction, Cardiovascular, Immunology, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC
Description	ELISA ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:100 - 1:200

Manual	FNab03087.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803081	FNab03087	100ug	$300		Add to Cart

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