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Home / Primary Antibodies / Polyclonal Antibodies

EYA3 antibody

SKU : BHA10802909

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Mfr.No.	FNab02915
Background	This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alteative splicing of this gene results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
Host	Rabbit
Immunogen	eyes absent homolog 3 (Drosophila)
Isotype	IgG
Molecular Weight	63 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	Q99504
Gene Id	2140
Research Area	Developmental biology, Metabolism, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IF, IHC, WB, IP
Description	ELISA ; IF ; IHC ; WB ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab02915.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802909	FNab02915	100ug	$300		Add to Cart

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