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Home / Primary Antibodies / Polyclonal Antibodies

ECD antibody

SKU : BHA10810326

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Mfr.No.	FNab10368
Background	Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP(PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes(PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins(PubMed:19640839). The cell cycle-regulating function may depend on its RUVBL1-mediated association with the R2TP complex(PubMed:26711270). May play a role in regulation of pre-mRNA splicing(PubMed:24722212).
Clonality	polyclonal
Host	Rabbit
Immunogen	ecdysoneless homolog(Drosophila)
Immunogen Region	ecdysoneless homolog(Drosophila)
Isotype	IgG
Molecular Weight	70-100 kDa
Reactivity	Human
Recommended Dilution	WB: 1:500-1:2000; IHC: 1:20-1:200
Synonyms	ECD, GCR2, HSGT1, Protein ecdysoneless homolog, Protein SGT1, SGT1, Suppressor of GCR2

Uniprot	O95905
Gene Id	11319
Research Area	Metabolism

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:2000; IHC: 1:20-1:200

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10368.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810326	FNab10368	100ug	$300		Add to Cart

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