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Home / Primary Antibodies / Polyclonal Antibodies

DNMT1 antibody

SKU : BHA10810563

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Mfr.No.	FNab10776
Background	Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation patte in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation pattes established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes(TSGs) or other tumor-related genes in colorectal cancer(CRC) cells(PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells(ESCs)(PubMed:24623306). Associates at promoter regions of tumor suppressor genes(TSGs) leading to their gene silencing(PubMed:24623306). Promotes tumor growth(PubMed:24623306).
Clonality	polyclonal
Host	Rabbit
Immunogen	DNA(cytosine-5-)-methyltransferase 1
Immunogen Region	DNA(cytosine-5-)-methyltransferase 1
Isotype	IgG
Reactivity	Human
Recommended Dilution	IHC: 1:20-1:200
Synonyms	AIM, CXXC9, DNA MTase HsaI, DNMT, DNMT1, MCMT

Uniprot	P26358
Gene Id	1786
Research Area	Epigenetics, Metabolism

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	IHC: 1:20-1:200

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10776.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810563	FNab10776	100ug	$300		Add to Cart

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