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Home / Primary Antibodies / Polyclonal Antibodies

DKK3 antibody

SKU : BHA10802397

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Mfr.No.	FNab02403
Alternative Names	REIC
Background	This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alteative splicing results in multiple transcript variants encoding the same protein.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a teary complex with the transmembrane protein KREMEN that promotes intealization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patteing, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Host	Rabbit
Immunogen	dickkopf homolog 3 (Xenopus laevis)
Isotype	IgG
Molecular Weight	38-55 kDa
Reactivity	Mouse, Rat
Regulatory	RUO
Synonyms	REIC

Uniprot	Q9UBP4
Gene Id	27122
Research Area	Developmental biology, Stem Cells

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, FC
Description	ELISA ; WB ; IHC ; FC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab02403.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802397	FNab02403	100ug	$300		Add to Cart

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