Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element(CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Clonality
polyclonal
Host
Rabbit
Immunogen
cAMP responsive element binding protein 1
Immunogen Region
cAMP responsIVe element binding protein 1
Isotype
IgG
Molecular Weight
43-46 kDa
Reactivity
Human, Mouse, Rat, Monkey
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Synonyms
CREB, CREB 1, CREB1
Uniprot
P16220
Gene Id
1385
Research Area
Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Neuroscience
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09947.pdf" target="_blank">Data Sheet</ a>