This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alteatively spliced transcript variants encoding different isoforms have been described for this gene.
Categories
Primary Antibodies
Clonality
polyclonal
Description
GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Host
Rabbit
Immunogen
chimerin (chimaerin) 1
Isotype
IgG
Molecular Weight
53 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
ARHGAP2, CHN
Uniprot
P15882
Gene Id
1123
Research Area
Signal Transduction, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)