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Home / Primary Antibodies / Promotion

CHD1 antibody

SKU : BHA10801635

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Mfr.No.	FNab01640
Background	The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.
Categories	Primary Antibodies
Clonality	polyclonal
Description	ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
Host	Rabbit
Immunogen	chromodomain helicase DNA binding protein 1
Isotype	IgG
Molecular Weight	197 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	O14646
Gene Id	1105
Research Area	Stem Cells, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:100 - 1:200

Manual	FNab01640.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801635	FNab01640	100ug	$300		Add to Cart

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