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Home / Primary Antibodies / Polyclonal Antibodies

CES1 antibody

SKU : BHA10801610

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Mfr.No.	FNab01615
Alternative Names	CES2 ; SES1
Background	This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.
Host	Rabbit
Immunogen	carboxylesterase 1 (monocyte/macrophage serine esterase 1)
Isotype	IgG
Molecular Weight	62 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	CES2, SES1

Uniprot	P23141
Gene Id	1066
Research Area	Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab01615.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801610	FNab01615	100ug	$300		Add to Cart

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