The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alteatively spliced transcript variants that encode the same protein have been described for this gene.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.
Host
Rabbit
Immunogen
CD151 molecule (Raph blood group)
Isotype
IgG
Molecular Weight
28 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
TSPAN24
Uniprot
P48509
Gene Id
977
Research Area
Stem Cells, Immunology, Cardiovascular, Signal Transduction
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)