Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. It is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. Caspase-12 is located in the endoplasmic reticulum (ER). It is responsible for ER-stress-induced apoptosis, such as high calcium concentration, low oxygen and low glucose levels. This antibody detects endogenous levels of full-length caspase-12 protein (50 kDa) and its cleaved product (40-44 kDa).
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
caspase 12(gene/pseudogene)
Isotype
IgG
Molecular Weight
36-42 kDa, 50 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
CASP12, CASP-12, CASP12P1
Uniprot
Q6UXS9
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)