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Home / Primary Antibodies / Promotion

BRCA2 antibody

SKU : BHA10810408

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Mfr.No.	FNab10454
Background	Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA(ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A(RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex(transcription and export complex 2) subunits PCID2 and SHFM1/DSS1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination(PubMed:24896180).
Clonality	polyclonal
Host	Rabbit
Immunogen	breast cancer 2, early onset
Immunogen Region	breast cancer 2, early onset
Isotype	IgG
Molecular Weight	384kd
Reactivity	Human
Recommended Dilution	WB: 1:200-1:1000
Synonyms	FACD, FANCD1, breast cancer 2, early onset, BROVCA2

Uniprot	P51587
Gene Id	675
Research Area	Epigenetics, Cancer, Metabolism

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:200-1:1000

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10454.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810408	FNab10454	100ug	$300		Add to Cart

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