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Home / Primary Antibodies / Promotion

BNIP3L antibody

SKU : BHA10800924

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Mfr.No.	FNab00929
Alternative Names	BNIP3A ; BNIP3H ; NIX
Background	This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
Host	Rabbit
Immunogen	BCL2/adenovirus E1B 19kDa interacting protein 3-like
Isotype	IgG
Molecular Weight	30 kDa, 45 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	BNIP3A, BNIP3H, NIX

Uniprot	O60238
Gene Id	665
Research Area	Cardiovascular

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab00929.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800924	FNab00929	100ug	$300		Add to Cart

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