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Home / Primary Antibodies / Polyclonal Antibodies

AKR7A2 antibody

SKU : BHA10800264

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Mfr.No.	FNab00266
Alternative Names	AFAR ; AFAR1 ; AFB1aldehydereductase1 ; AFB1AR1 ; AFB1AR1 ; AKR7 ; AKR7A2 ; Aldoketoreductase7 ; SSAreductase
Background	The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alteative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Golgi Apparatus
Clonality	polyclonal
Description	Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Host	Rabbit
Immunogen	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
Isotype	IgG
Molecular Weight	40 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Subcellular Location	Cytoplasm, Golgi apparatus
Synonyms	AFAR, AFAR1, AFB1 aldehyde reductase 1, AFB1 AR 1, AFB1 AR1, AKR7, AKR7A2, Aldoketoreductase 7, SSA reductase

Uniprot	O43488
Gene Id	8574
Research Area	Metabolism
Weight	40kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:1000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100

Manual	FNab00266.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800264	FNab00266	100ug	$300		Add to Cart

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