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Home / Primary Antibodies / Promotion

AIF antibody

SKU : BHA10800233

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Mfr.No.	FNab00235
Alternative Names	AIF ; AIFM1 ; PDCD8
Background	This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alteative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Membrane, Mitochondria, Mitochondrion Inner Membrane, Nucleus
Clonality	polyclonal
Description	Apoptosis-inducing factor (AIF) is one of the mitochondrial proteins to be released into the cytosol during apoptosis, and it is discovered as the first protein that regulates caspase-independent apoptosis(PMID:20494118). AIF is encoded as a 67 kDa protein that contains a mitochondrial localization signal (MLS) in the N-terminus.It is cleaved from the 62 kDa to the 57 kDa form following ischemic injury and translocated from the mitochondria to the nucleus in a calpain-dependent manner(PMID:19332058).
Host	Rabbit
Immunogen	apoptosis-inducing factor, mitochondrion-associated, 1
Isotype	IgG
Molecular Weight	67 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Subcellular Location	Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus
Synonyms	AIF, AIFM1, PDCD8

Uniprot	O95831
Gene Id	9131
Research Area	Metabolism, Neuroscience
Weight	66kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB, IP, IF

Description

ELISA ; IHC ; WB ; IP ; IF

Dilution

WB	1:1000-1:10000
IP	1:1000-1:10000
IF	1:10-1:100
IHC	1:100-400

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab00235.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800233	FNab00235	100ug	$300		Add to Cart

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