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Home / Primary Antibodies / Polyclonal Antibodies

AGO2 antibody

SKU : BHA10800212

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Mfr.No.	FNab00214
Alternative Names	AGO2 ; Argonaute2 ; eIF2C2 ; eIF2C2 ; EIF2C2 ; hAgo2 ; PAZPiwidomainprotein ; PPD ; Proteinargonaute2 ; Proteinslicer ; Q10
Background	This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nucleus
Clonality	polyclonal
Description	Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
Host	Rabbit
Immunogen	eukaryotic translation initiation factor 2C, 2
Isotype	IgG
Molecular Weight	100 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Nucleus
Synonyms	AGO2, Argonaute2, eIF 2C 2, eIF2C 2, EIF2C2, hAgo2, PAZ Piwi domain protein, PPD, Protein argonaute 2, Protein slicer, Q10

Uniprot	Q9UKV8
Gene Id	27161
Research Area	Epigenetics, Metabolism
Weight	97kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IP

Description

ELISA ; WB ; IP

Dilution

WB	1:200-1:2000
IP	1:200-1:2000

Tested Application

WB: 1:500 - 1:1000; IHC: 1:50 - 1:200

Manual	FNab00214.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800212	FNab00214	100ug	$300		Add to Cart

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