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Home / Primary Antibodies / Promotion

Aggrecan antibody

SKU : BHA10800211

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Mfr.No.	FNab00213
Alternative Names	ACAN ; AGC1 ; AGCAN ; aggrecan ; CSPG1 ; CSPGCP ; MSK16 ; SEDK
Background	Aggrecan(ACAN), also named as CSPCP, AGC1 and MSK16, belongs to the aggrecan/versican proteoglycan family(also including versican, brevican and neurocan). It is a major component of extracellular matrix of cartilagenous tissues. A major function of aggrecan is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. This polyclonal antibody raised against 1-298aa of human aggrecan reveals a band of 70 kDa, which is consistent with the molecular weight of degradation product generated by proteolysis at the aggrecanase site(PMID: 7852317; 9337874).
Categories	Primary Antibodies
Cellular Localization	Extracellular matrix, Secreted
Clonality	polyclonal
Description	Aggrecan (ACAN), also named as CSPCP, AGC1 and MSK16, belongs to the aggrecan/versican proteoglycan family (also including versican, brevican and neurocan). It is a major component of extracellular matrix of cartilagenous tissues. A major function of aggrecan is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. This polyclonal antibody raised against 1-298aa of human aggrecan reveals a band of 70 kDa, which is consistent with the molecular weight of degradation product generated by proteolysis at the aggrecanase site (PMID: 7852317; 9337874).
Host	Rabbit
Immunogen	aggrecan
Isotype	IgG
Molecular Weight	70 kDa, 250-260 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Extracellular matrix, Secreted
Synonyms	ACAN, AGC1, AGCAN, aggrecan, CSPG1, CSPGCP, MSK16, SEDK

Uniprot	P16112
Research Area	Developmental biology, Stem Cells, Cardiovascular, Metabolism
Weight	250kDa,observed 70kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:200-1:2000
IHC	1:20-1:200

Tested Application

WB: 1:500-1:1000; IHC: 1:20-1:200

Manual	FNab00213.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800211	FNab00213	100ug	$300		Add to Cart

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