Antagonizes the binding of 2-5A(5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA tuover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Categories
Primary Antibodies
Cellular Localization
Cytoplasm, Mitochondria
Clonality
polyclonal
Description
Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA tuover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Host
Rabbit
Immunogen
ATP-binding cassette, sub-family E(OABP), member 1
Isotype
IgG
Molecular Weight
67 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Subcellular Location
Cytoplasm, Mitochondrion
Synonyms
ABCE1, RLI, RNase L inhibitor, RNASEL1, OABP
Uniprot
P61221
Gene Id
6059
Research Area
Metabolism
Weight
67kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)