• Alternative Names :
• Tau-tubulin kinase 2 (EC 2.7.11.1), TTBK2, KIAA0847

• Antigen :
• TTBK2

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Conjugate :
• Non-conjugated

• Description :
• Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Tau-tubulin kinase 2 protein (1185-1244AA)

• Involvement In Disease :
• Spinocerebellar ataxia 11 (SCA11)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cell projection, cilium, Cytoplasm, cytoskeleton, cilium basal body, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Cytoplasm, cytosol, Nucleus

• Uniprot :
• Q6IQ55

• Database Links :
• 
  

  HGNC:19141

  OMIM:604432

  KEGG:hsa:146057

  STRING:9606.ENSP00000267890

  UniGene:Hs.646511

• Function :
• Serine/threonine kinase that acts as a key regulator of ciliogenesis

• Protein Families :
• Protein kinase superfamily, CK1 Ser/Thr protein kinase family

• Research Area :
• Signal Transduction

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :