• Alternative Names :
• Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2), DVL2

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes .

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Segment polarity protein dishevelled homolog DVL-2 protein (1-240AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes .

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, cytosol, Cytoplasmic vesicle, Nucleus

• Uniprot :
• O14641

• Database Links :
• 
  

  HGNC:3086

  OMIM:602151

  KEGG:hsa:1856

  STRING:9606.ENSP00000005340

  UniGene:Hs.118640

• Function :
• Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.

• Pathway :
• Hippo signaling pathway Melanogenesis mTOR signaling pathway Notch signaling pathway Wnt signaling pathway Signaling pathways regulating pluripotency of stem cells

• Protein Families :
• DSH family

• Research Area :
• Stem Cells

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunofluorescence (IF) Protocol :