• Alternative Names :
• E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1), RNF125

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human E3 ubiquitin-protein ligase RNF125 protein (1-232AA)

• Involvement In Disease :
• Tenorio syndrome (TNORS)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Golgi apparatus membrane, Lipid-anchor

• Uniprot :
• Q96EQ8

• Database Links :
• 
  

  HGNC:21150

  OMIM:610432

  KEGG:hsa:54941

  STRING:9606.ENSP00000217740

  UniGene:Hs.633703

• Function :
• E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53

• Research Area :
• Cell Biology

• Tissue Specificity :
• Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :