• Alternative Names :
• TNF receptor-associated factor 5 (RING finger protein 84), TRAF5, RNF84

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human TNF receptor-associated factor 5 protein (1-300AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, Cytoplasm, cytosol

• Uniprot :
• O00463

• Database Links :
• 
  

  HGNC:12035

  OMIM:602356

  KEGG:hsa:7188

  STRING:9606.ENSP00000261464

  UniGene:Hs.523930

• Function :
• Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

• Pathway :
• NF-kappa B signaling pathway TNF signaling pathway Necroptosis IL-17 signaling pathway NOD-like receptor signaling pathway

• Protein Families :
• TNF receptor-associated factor family, A subfamily

• Research Area :
• Immunology

• Tissue Specificity :
• Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :