• Alternative Names :
• Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP), SNCA, NACP PARK1

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Sites

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Alpha-synuclein protein (61-140AA)

• Involvement In Disease :
• Parkinson disease 1, autosomal dominant (PARK1); Parkinson disease 4, autosomal dominant (PARK4); Dementia Lewy body (DLB)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Sites

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, cytosol, Membrane, Nucleus, Cell junction, synapse, Secreted

• Uniprot :
• P37840

• Gene Id :
• 6622

• Database Links :
• 
  

  HGNC:11138

  OMIM:127750

  KEGG:hsa:6622

  STRING:9606.ENSP00000338345

  UniGene:Hs.21374

• Function :
• May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

• Protein Families :
• Synuclein family

• Research Area :
• Neuroscience

• Tissue Specificity :
• Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.

• Weight :
• 14460 MW

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :