• Alternative Names :
• Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-DH) (11-beta-HSD1) (Short chain dehydrogenase/reductase family 26C member 1), HSD11B1, HSD11 HSD11L SDR26C1

• Antigen :
• HSD11B1

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Conjugate :
• Non-conjugated

• Description :
• Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Corticosteroid 11-beta-dehydrogenase isozyme 1 protein (25-292AA)

• Involvement In Disease :
• Cortisone reductase deficiency 2 (CORTRD2)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human, Mouse

• Regulatory :
• RUO

• Relevance :
• Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Endoplasmic reticulum membrane, Single-pass type II membrane protein

• Uniprot :
• P28845

• Database Links :
• 
  

  HGNC:5208

  OMIM:600713

  KEGG:hsa:3290

  STRING:9606.ENSP00000261465

  UniGene:Hs.195040

• Function :
• Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

• Protein Families :
• Short-chain dehydrogenases/reductases (SDR) family

• Research Area :
• Signal Transduction

• Tissue Specificity :
• Widely expressed. Highest expression in liver.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :