• Alternative Names :
• NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (Clan protein) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf), NLRC4, CARD12 CLAN CLAN1 IPAF

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human NLR family CARD domain-containing protein 4 protein (1-250AA)

• Involvement In Disease :
• Autoinflammation with infantile enterocolitis (AIFEC); Familial cold autoinflammatory syndrome 4 (FCAS4)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, Cytoplasm, cytosol

• Uniprot :
• Q9NPP4

• Database Links :
• 
  

  HGNC:16412

  OMIM:606831

  KEGG:hsa:58484

  STRING:9606.ENSP00000354159

  UniGene:Hs.574741

• Function :
• Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.

• Pathway :
• Inflammasome Signaling NOD-like receptor signaling pathway

• Research Area :
• Immunology

• Tissue Specificity :
• Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isofo

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity purified

• Purity :
• Antigen Affinity purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :