• Alternative Names :
• Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain), TRADD

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein (1-312AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Nucleus, Cytoplasm, Cytoplasm, cytoskeleton

• Uniprot :
• Q15628

• Database Links :
• 
  

  HGNC:12030

  OMIM:603500

  KEGG:hsa:8717

  STRING:9606.ENSP00000341268

  UniGene:Hs.460996

• Function :
• The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12

• Pathway :
• MAPK signaling pathway NF-kappa B signaling pathway TNF signaling pathway Apoptosis Necroptosis IL-17 signaling pathway Adipocytokine signaling pathway

• Research Area :
• Cell Biology

• Tissue Specificity :
• Found in all examined tissues.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :