KCNN4 Antibody

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KCNN4 Antibody

Alternative Names Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos...
Antigen KCNN4
Categories Primary Antibodies

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Description

Description

Alternative Names :
Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel), KCNN4, IK1 IKCA1 KCA4 SK4

Antigen :
KCNN4

Categories :
Primary Antibodies

Clonality :
polyclonal

Conjugate :
Non-conjugated

Description :
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.

Host :
Rabbit

Immunogen :
Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 protein (288-427AA)

Involvement In Disease :
Dehydrated hereditary stomatocytosis 2 (DHS2)

Isotype :
IgG

Raised In :
Rabbit

Reactivity :
Human

Regulatory :
RUO

Relevance :
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.

Species :
Homo Sapiens (Human)

Subcellular Location :
Cell membrane, Multi-pass membrane protein

Target

Target

Uniprot :
O15554

Database Links :
HGNC:6293
OMIM:602754
KEGG:hsa:3783
STRING:9606.ENSP00000262888
UniGene:Hs.10082

Function :
Forms a voltage-independent potassium channel that is activated by intracellular calcium

Protein Families :
Potassium channel KCNN family, KCa3.1/KCNN4 subfamily

Research Area :
Neuroscience

Tissue Specificity :
Widely expressed in non-excitable tissues.

Property

Property

Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form :
Liquid

Format :
Liquid

Purification :
Antigen Affinity Purified

Purity :
Antigen Affinity Purified

Storage :
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Storage Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

Applications

Application

Description

Dilution

Dilution: ELISA, WB, IHC

Dilution: ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution:

WB	1:500-5000
IHC	1:20-1:200

Dilution: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Protocols

Protocols

Datasheet :

ELISA Protocol :

Western Blotting(WB) Protocol :

Immunohistochemistry (IHC) Protocol :

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