• Alternative Names :
• Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2), IFNAR2, IFNABR IFNARB

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Interferon alpha/beta receptor 2 protein (27-243AA)

• Involvement In Disease :
• Immunodeficiency 45 (IMD45)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 3: Secreted

• Uniprot :
• P48551

• Database Links :
• 
  

  HGNC:5433

  OMIM:602376

  KEGG:hsa:3455

  STRING:9606.ENSP00000343957

  UniGene:Hs.708195

• Function :
• Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation

• Pathway :
• Jak-STAT signaling pathway PI3K-Akt signaling pathway Necroptosis Natural killer cell mediated cytotoxicity NOD-like receptor signaling pathway Osteoclast differentiation Toll-like receptor signaling pathway

• Protein Families :
• Type II cytokine receptor family

• Research Area :
• Immunology

• Tissue Specificity :
• Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :