BCL10 Antibody

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BCL10 Antibody

Alternative Names B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP)...
Categories Primary Antibodies
Clonality polyclonal

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suppilerCUSABIO TECHONOLOGY LLC
merchant skuCSB-PA002608ESR2HU
item price299.00000
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suppilerCOHESION BIOSCIENCES
merchant skuCSB-PA002608ESR2HU
item price168.78000
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Description

Description

Alternative Names :
B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10), BCL10, CIPER CLAP

Categories :
Primary Antibodies

Clonality :
polyclonal

Description :
Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.

Host :
Rabbit

Immunogen :
Recombinant Human B-cell lymphoma/leukemia 10 protein (1-233AA)

Involvement In Disease :
Immunodeficiency 37 (IMD37); Lymphoma, mucosa-associated lymphoid type (MALTOMA)

Isotype :
IgG

Raised In :
Rabbit

Reactivity :
Human, Mouse

Regulatory :
RUO

Relevance :
Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.

Species :
Homo Sapiens (Human)

Subcellular Location :
Cytoplasm, perinuclear region, Membrane raft

Target

Target

Uniprot :
O95999

Database Links :
HGNC:989
OMIM:137245
KEGG:hsa:8915
STRING:9606.ENSP00000271015
UniGene:Hs.193516

Function :
Involved in adaptive immune response

Pathway :
NF-kappa B signaling pathway B cell receptor signaling pathway T cell receptor signaling pathway

Research Area :
Cell Biology

Tissue Specificity :
Ubiquitous.

Property

Property

Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form :
Liquid

Format :
Liquid

Purification :
Antigen Affinity purified

Purity :
Antigen Affinity purified

Storage :
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Storage Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

Applications

Application

Description

Dilution

Dilution: ELISA, WB, IHC

Dilution: ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution:

WB	1:500-2000
IHC	1:20-1:200

Dilution: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

References

References

Reference :
- Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression Mrquez-Jurado S.et al,Nat Commun,Jan 26

Protocols

Protocols

Datasheet :

ELISA Protocol :

Western Blotting(WB) Protocol :

Immunohistochemistry (IHC) Protocol :

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