• Alternative Names :
• V-type proton ATPase 116 kDa subunit a isoform 2 (V-ATPase 116 kDa isoform a2) (Lysosomal H(+)-transporting ATPase V0 subunit a2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2), ATP6V0A2

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human V-type proton ATPase 116 kDa subunit a isoform 2 protein (476-549AA)

• Involvement In Disease :
• Cutis laxa, autosomal recessive, 2A (ARCL2A); Wrinkly skin syndrome (WSS)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cell membrane, Multi-pass membrane protein, Endosome membrane

• Uniprot :
• Q9Y487

• Gene Id :
• 23545

• Database Links :
• 
  

  HGNC:18481

  OMIM:219200

  KEGG:hsa:23545

  STRING:9606.ENSP00000332247

  UniGene:Hs.25786

• Function :
• Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation

• Pathway :
• Oxidative Phosphorylation Synaptic vesicle cycle

• Protein Families :
• V-ATPase 116 kDa subunit family

• Research Area :
• Signal Transduction

• Weight :
• 98,082 Da

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• >95%, Protein G purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Datasheet :
• 

• ELISA Protocol :