GDF5 Antibody

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GDF5 Antibody

Alternative Names Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1)...
Antigen Gdf5
Categories Primary Antibodies

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suppilerCUSABIO TECHONOLOGY LLC
merchant skuCSB-PA009349ESR1HU
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Description

Description

Alternative Names :
Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin), GDF5, BMP14 CDMP1

Antigen :
Gdf5

Categories :
Primary Antibodies

Clonality :
polyclonal

Conjugate :
Non-conjugated

Description :
Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Host :
Rabbit

Immunogen :
Recombinant Human Growth/differentiation factor 5 protein (202-501AA)

Involvement In Disease :
Acromesomelic chondrodysplasia, Grebe type (AMDG); Acromesomelic chondrodysplasia, Hunter-Thompson type (AMDH); Brachydactyly C (BDC); Du Pan syndrome (DPS); Symphalangism, proximal 1B (SYM1B); Multiple synostoses syndrome 2 (SYNS2); Brachydactyly A2 (BDA2); Osteoarthritis 5 (OS5); Brachydactyly A1, C (BDA1C)

Isotype :
IgG

Raised In :
Rabbit

Reactivity :
Human

Regulatory :
RUO

Relevance :
Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Species :
Homo Sapiens (Human)

Subcellular Location :
Secreted, Cell membrane

Target

Target

Uniprot :
P43026

Database Links :
HGNC:4220
OMIM:112600
KEGG:hsa:8200
STRING:9606.ENSP00000363489
UniGene:Hs.1573

Function :
Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction

Pathway :
Hippo signaling pathway TGF-beta signaling pathway

Protein Families :
TGF-beta family

Research Area :
Cardiovascular

Tissue Specificity :
Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level).

Property

Property

Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form :
Liquid

Format :
Liquid

Purification :
Antigen Affinity Purified

Purity :
Antigen Affinity Purified

Storage :
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Storage Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

Applications

Application

Description

Dilution

Dilution: ELISA, IHC

Dilution: ELISA ; IHC, WB ; ELISA ; IHC ; IF

Dilution:

IHC	1:20-1:200

Dilution: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:20-1:200

Protocols

Protocols

Datasheet :

ELISA Protocol :

Western Blotting(WB) Protocol :

Immunofluorescence (IF) Protocol :

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