• Alternative Names :
• Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2) (Desnutrin) (IPLA2-zeta) (Pigment epithelium-derived factor) (TTS2.2) (Transport-secretion protein 2) (TTS2), PNPLA2, ATGL

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Patatin-like phospholipase domain-containing protein 2 protein (1-504AA)

• Involvement In Disease :
• Neutral lipid storage disease with myopathy (NLSDM)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Lipid droplet, Cell membrane, Single-pass type II membrane protein

• Uniprot :
• Q96AD5

• Gene Id :
• 57104

• Database Links :
• 
  

  HGNC:30802

  OMIM:609059

  KEGG:hsa:57104

  STRING:9606.ENSP00000337701

  UniGene:Hs.654697

• Function :
• Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets

• Research Area :
• Cardiovascular

• Tissue Specificity :
• Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner seg

• Weight :
• 19,875 Da

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• >95%, Protein G purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Datasheet :
• 

• ELISA Protocol :