• Alternative Names :
• Mitochondrial RNA pseudouridine synthase RPUSD4 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 4), RPUSD4

• Antigen :
• RPUSD4

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Conjugate :
• Biotin

• Description :
• mitochondrion, poly(A) RNA binding, pseudouridine synthase activity, tRNA pseudouridine synthesis

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Mitochondrial RNA pseudouridine synthase RPUSD4 protein (41-240AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Mitochondrion matrix

• Uniprot :
• Q96CM3

• Database Links :
• 
  

  HGNC:25898

  KEGG:hsa:84881

  STRING:9606.ENSP00000298317

  UniGene:Hs.150458

• Function :
• Converts specific uridines to pseudouridine (PSI) in different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome

• Protein Families :
• Pseudouridine synthase RluA family

• Research Area :
• Others

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Datasheet :
• 

• ELISA Protocol :