• Alternative Names :
• Telomere repeats-binding bouquet formation protein 1 (Coiled-coil domain-containing protein 79), TERB1, CCDC79

• Antigen :
• TERB1

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Conjugate :
• FITC

• Description :
• Meiosis-specific telomere-associated protein involved in meiotic telomere clustering, also named bouquet formation, the telomere-mediated chromosomal movement along the nuclear envelope which is crucial for homologous pairing and synapsis. Probably acts as a hub for the assembly of a conserved meiotic telomere complex required for chromosome movements via interaction with TERF1. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Telomere repeats-binding bouquet formation protein 1 protein (301-550AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Meiosis-specific telomere-associated protein involved in meiotic telomere clustering, also named bouquet formation, the telomere-mediated chromosomal movement along the nuclear envelope which is crucial for homologous pairing and synapsis. Probably acts as a hub for the assembly of a conserved meiotic telomere complex required for chromosome movements via interaction with TERF1. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Chromosome, telomere, Nucleus inner membrane

• Uniprot :
• Q8NA31

• Database Links :
• 
  

  HGNC:26675

  OMIM:617332

  KEGG:hsa:283847

  STRING:9606.ENSP00000462883

  UniGene:Hs.376505

• Function :
• Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes

• Protein Families :
• TERB1 family

• Research Area :
• Others

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• >95%, Protein G purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Datasheet :
• 

• ELISA Protocol :