• Alternative Names :
• Apoptosis-enhancing nuclease (EC 3.1.-.-) (Interferon-stimulated 20 kDa exonuclease-like 1), AEN, ISG20L1

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Apoptosis-enhancing nuclease protein (117-325AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Nucleus, Nucleus, nucleolus

• Uniprot :
• Q8WTP8

• Gene Id :
• 64782

• Database Links :
• 
  

  HGNC:25722

  OMIM:610177

  KEGG:hsa:64782

  STRING:9606.ENSP00000331944

  UniGene:Hs.436102

• Function :
• Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.

• Research Area :
• Cell Biology

• Weight :
• 36kDa

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• >95%, Protein G purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Datasheet :
• 

• ELISA Protocol :

• Immunofluorescence (IF) Protocol :