• Alternative Names :
• Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha), PARD3, PAR3 PAR3A

• Antigen :
• PARD3

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Conjugate :
• FITC

• Description :
• Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Partitioning defective 3 homolog protein (1068-1356AA)

• Involvement In Disease :
• Neural tube defects (NTD)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, Endomembrane system, Cell junction, Cell junction, tight junction, Cell junction, adherens junction, Cell membrane, Cytoplasm, cell cortex, Cytoplasm, cytoskeleton

• Uniprot :
• Q8TEW0

• Database Links :
• 
  

  HGNC:16051

  OMIM:182940

  KEGG:hsa:56288

  STRING:9606.ENSP00000363921

  UniGene:Hs.131489

• Function :
• Adapter protein involved in asymmetrical cell division and cell polarization processes

• Pathway :
• Chemokine signaling pathway Hippo signaling pathway Adherens junction Rap1 signaling pathway Endocytosis

• Protein Families :
• PAR3 family

• Research Area :
• Signal Transduction

• Tissue Specificity :
• Widely expressed.

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• >95%, Protein G purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Datasheet :
• 

• ELISA Protocol :