• Alternative Names :
• DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1), RFX6, RFXDC1

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).

• Host :
• Rabbit

• Immunogen :
• Recombinant Human DNA-binding protein RFX6 protein (1-260AA)

• Involvement In Disease :
• Mitchell-Riley syndrome (MTCHRS)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Nucleus

• Uniprot :
• Q8HWS3

• Database Links :
• 
  

  HGNC:21478

  OMIM:612659

  KEGG:hsa:222546

  STRING:9606.ENSP00000332208

  UniGene:Hs.352276

• Function :
• Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin

• Protein Families :
• RFX family

• Research Area :
• Others

• Tissue Specificity :
• Expressed in pancreas (PubMed:25497100). Expressed in pancreatic beta-cells (insulin-positive cells) and alpha-cells (glucagon-positive cells) (at protein level). Specifically expressed in pancreas, small intestine and colon (PubMed:20148032). Expressed i

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• >95%, Protein G purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Datasheet :
• 

• ELISA Protocol :