• Alternative Names :
• Transmembrane protease serine 6 (EC 3.4.21.-) (Matriptase-2), TMPRSS6

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Transmembrane protease serine 6 protein (98-301AA)

• Involvement In Disease :
• Iron-refractory iron deficiency anemia (IRIDA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cell membrane, Single-pass type II membrane protein

• Uniprot :
• Q8IU80

• Database Links :
• 
  

  HGNC:16517

  OMIM:206200

  KEGG:hsa:164656

  STRING:9606.ENSP00000334962

  UniGene:Hs.370885

• Function :
• Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.

• Protein Families :
• Peptidase S1 family

• Research Area :
• Signal Transduction

• Tissue Specificity :
• Liver specific.

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• >95%, Protein G purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Datasheet :
• 

• ELISA Protocol :