Rat Spinal Cord Motor Neurons (RSCMN)

Product Description

The spinal cord is the most important structure between the body and the brain. The spinal cord extends from the foramen magnum where it is continuous with the medulla to the level of the first or second lumbar vertebrae ⁽¹⁾. The spinal cord is composed of tubular bundles of nervous tissues and support cells. Extending from the occipital bone of the skull until it terminates near the second lumbar vertebra, the spinal cord transmits neural signals from the motor cortex to the body, and from the afferent fibers of the sensory neurons to the sensory cortex. It is also a center for coordinating many reflexes and contains reflex arcs that can independently control reflexes ⁽²⁾. Studies using spinal cord neurons will allow a better understanding of the disease mechanisms, physiopathologies, and advancement in drug development and therapies. Cultures of spinal cord neurons can be applied for a variety of experiments including cytotoxicity test, immunocytochemistry staining, live cell imaging and co-culture, etc.

iXCells Biotechnologies provides high quality Rat Spinal Cord Motor Neurons (RSCMN), which are isolated from D16 rat embryo spinal cord and cryopreserved at P0, with >0.2 million cells in each vial. When cultured under the recommended conditions, RSCMN arborize and form complex neurite network since about 4-5 days till one week. RSpN stain positive for Tuj1 and MAP2. RSCMN are negative for mycoplasma, bacteria, yeast, and fungi.

Figure 1. (A) Phase contrast image of Rat Spinal Cord Motor Neurons (RSCMN) (DIV 4). (B) RSCMN are positive for beta III-Tubulin (TUJ1) and MAP2 as shown by immunofluorescence staining.

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References

(1) Squire, Larry Squire; et al. (2013). Fundamental neuroscience (4th ed.). Amsterdam: Elsevier/Academic Press. p.628.

(2) Guertin, PA (2012). "Central pattern generator for locomotion: anatomical, physiological, and pathophysiological considerations". Frontiers in Neurology. 3: 183.

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