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Human Thymic Epithelial Cells

SKU : BHC18001370

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AcceGen Biotech

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Mfr.No.	ABC-TC5517
Description	Thymic epithelial cells (TyEpiC) are major component of thymic stroma with a high degree of phenotypical and functional heterogeneity. They can be broadly categorized into cortical and medullary thymic epithelial cells. Primary thymic epithelial cells are indispensable to the thymopoeisis and stepwise development of T cells. Immature thymocytes are selected by the MHC complexes presented on thymic epithelial cell surface and become self-tolerant and functionally competent T cells. Dysfunction of thymic epithelial cells is often associated with autoimmune disease and immunodeficiency. AcceGen Human thymic epithelial cells are isolated from healthy human thymus. Cells at passage 3 are cryopreserved to ensure best viability. Each vial contains more than 5×10^5 cells in 1ml volume. Human thymic epithelial cells are tested for expression of E-cadherin or ZO-1 using immunofluorescence. All cell lots are tested negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi and other pathogens. Human thymic epithelial cells are guaranteed for further expansion following protocols provided by AcceGen. Human thymic epithelial cells have limited expansion capacity and as a result are not recommended for long-term culturing.
Categories	Primary Cells
Cell Type	Epithelial
Applications Range	For research use only Due to their importance in orchestrating immune system, thymic epithelial cells have become attractive target for cell therapies and can have wide application in research and clinical settings, including: Identification and characterization of sub-populations. Interaction with various transcription factors, such as autoimmune regulator AIRE, and the impact on thymic microenvironment. Expression of peripheral antigens on thymic epithelial cells that facilitate positive and negative selection of T cells. Autoimmune and inflammatory diseases associated with thymic epithelial cell dysfunction. Cytokines, chemokines, costimulatory molecules, and transcription factors expression of thymic epithelial cells under various stimulations. Other research considering thymic epithelial cells function, developmental progress, and reconstitution after surgery.
Culture Medium	ABM-TM5517 Human Thymic Epithelial Cells Medium Kit
Disease	Normal
Features	Backed by AcceGen advanced technology Cryopreserved for highest viability and plating efficiency Quality-tested for accurate results Expert teams to provide timely support and assist best experimental outcomes
Growth Properties	37 ℃, 5% CO2
Tissue	Thymus
Species	Human
Applications	For research use only

Shipping	Dry Ice
Storage	Liquid Nitrogen
Quality Control	All cells test negatIVe for mycoplasma, bacteria, yeast, and fungi.

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SKU	Supplier No.	Your price	Quantity
BHC18001370	ABC-TC5517	-		Add to Quote

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