Human Retinal Pigment Epithelial Cells are major components of the human retina, a multi-layered lining of the rear surface of the eye. They are different from many other types of epithelia in the polarity of a number of proteins, and their apical plasma membrane is in contact with the extracellular matrix rather than devoid of matrix like other epithelial cell types. They are critical in the development and maintenance of adjacent photoreceptors in retina, playing a key role in maintaining normal vision and supports photo-transduction due to its anatomic location between the photoreceptors and the choriocapillaries. These cells are ideal models for research on ocular diseases and study of cell-matrix interactions, gene regulation and tissue development.
Cell Type
Primary Cells
Disease
Normal
Gender
Donor Info Not Disclosed
Growth Properties
Adherent
Quantity
5x105 cells / 1.0 ml
Tissue
Eye
Morphology
Polygonal
Species
Human (H. sapiens)
Propagation
Use of PriCoatTMT25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) is required for cell adhesion to the culture vessels. Grow cells inECM-coated culture vessels unless otherwise specified in the Propagation Requirements below.The base medium for this cell line is Prigrow X series medium available at abm, Cat. No. TM4057. Carbon dioxide (CO2): 5%, Temperature: 37.0
Applications
For Research Use Only
Reviews of Human Primary Retinal Microvascular Endothelial Cells