Human Dermal Fibroblasts-Type 1 Diabetes (HDF-T1D)

Product Description

Human Dermal Fibroblasts (HDF) are the most prevalent cell in human dermis, and one of the most important architects of cutaneous would healing ⁽¹⁾. The fibroblast is a malleable cell, capable of altering its function and physiology or even transforming into a new cell type, based on its location within the body. The dermal fibroblast also has the unique title of being the first human somatic cell to be induced into a pluripotent stem cell line ^(2,3).

iXCells Biotechnologies provides high quality Human Dermal Fibroblasts (HDF) from normal donors including neonatal foreskin (Cat# 10HU-013) and adult skin (Cat# 10HU-014), or from adult skin of Type 1 Diabetes patients. These cells are derived from the dermis of normal human neonatal foreskin or adult skin and cryopreserved at the end of primary culture. HDF are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand in Fibroblast Growth Medium (Cat# MD-0011) for no more than 3 passages under the condition suggested by iXCells Biologies. Further expansion may decrease the proliferation rate and purity.

Figure 1. (A) Human Neonatal Dermal Fibroblasts (10HU-013).  (B) Human Adult Dermal Fibroblasts (10HU-014).

Product Details

References

(1) Lauren E. Tracy, Raquel A. Minasian, and E.J. Caterson (2016) Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound. Adv Wound Care (New Rochelle). 2016 Mar 1; 5(3): 119–136.

(2) Takahashi K, Yamanaka S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell; 126:663–676.

(3) Kazutoshi Takahashi 1, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell; 131:861–872. 

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