Zinc finger protein 18; Zinc finger protein KOX11; Heart development-specific gene 1 protein; Zinc finger protein with KRAB and SCAN domains 6; ZNF18
Categories
Primary Antibodies
Clonality
polyclonal
Description
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence By similarity. Has transcription repressor activity in vitro.Guo L.L., Yi Chuan 27:523-530(2005).Ota T., Nat. Genet. 36:40-45(2004).Thiesen H.-J., New Biol. 2:363-374(1990).
Host
Rabbit
Immunogen
Synthesized peptide derived from N-terminal of Human ZNF24.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence By similarity. Has transcription repressor activity in vitro.
Guo L.L., Yi Chuan 27:523-530(2005). Ota T., Nat. Genet. 36:40-45(2004). Thiesen H.-J., New Biol. 2:363-374(1990).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ZNF24 protein.
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.
Protein Families
Krueppel C2H2-type zinc-finger protein family
Tissue Specificity
Expressed in many tissues except in heart.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.